DNA icon

Noonan-Like Syndrome via the RRAS Gene

Summary and Pricing

Test Method

Sequencing and CNV Detection via NextGen Sequencing using PG-Select Capture Probes
Test Code Test Copy GenesTest CPT Code Gene CPT Codes Copy CPT Codes Base Price
10641 RRAS 81479 81479,81479 $990 Order Options and Pricing
Test Code Test Copy Genes Test CPT Code Gene CPT Codes Copy CPT Code Base Price
10641RRAS81479 81479,81479 $990 Order Options and Pricing

Pricing Comments

This test is also offered via our exome backbone with CNV detection (click here). The exome-based test may be higher priced, but permits reflex to the entire exome or to any other set of clinically relevant genes.

An additional 25% charge will be applied to STAT orders. STAT orders are prioritized throughout the testing process.

Testing run on PG-Select capture probes does not include exome-wide CNV analysis. Reflex is available to PGxome or an exome-based panel, or you can use this gene list to create a custom panel (click here).

Click here for costs to reflex to whole PGxome.

Turnaround Time

3 weeks on average for standard orders or 2 weeks on average for STAT orders.

Please note: Once the testing process begins, an Estimated Report Date (ERD) range will be displayed in the portal. This is the most accurate prediction of when your report will be complete and may differ from the average TAT published on our website. About 85% of our tests will be reported within or before the ERD range. We will notify you of significant delays or holds which will impact the ERD. Learn more about turnaround times here.

Targeted Testing

For ordering sequencing of targeted known variants, go to our Targeted Variants page.


Genetic Counselors


  • Brett Deml, PhD

Clinical Features and Genetics

Clinical Features

Noonan Syndrome (NS) is characterized by dysmorphic facial features, growth and congenital heart defects, and musculoskeletal abnormalities. Cardiac abnormalities are found in up to 80% of patients and include pulmonary valve stenosis, atrial septal defect, atrioventricular canal defect, and hypertrophic cardiomyopathy. Musculoskeletal abnormalities include short stature, chest deformity with sunken or raised sternum, and short webbed neck. Several additional abnormalities have been described and include renal, genital, hematological, neurologic, cognitive, behavioral, gastrointestinal, dental, and lymphatic findings. Intelligence is usually normal; however, learning disabilities may be present. NS is characterized by extensive clinical heterogeneity, even among members of the same family. Diagnosis is often made in infancy or early childhood. Symptoms often change and lessen with advancing age. Infants with NS are at risk of developing juvenile myelomonocytic leukemia (JMML). The prevalence of NS is estimated at 1 in 1,000 to 1 in 2,500 births worldwide (Allanson. 1987. PubMed ID: 3543368; Romano et al. 2010. PubMed ID: 20876176; Smpokou et al. 2012. PubMed ID: 23165751; Cao et al. 2017. PubMed ID: 28643916; Allanson and Roberts. 2016. PubMed ID: 20301303).

Clinical features of Noonan syndrome overlap with those of Cardio-Facio-Cutaneous Syndrome (Gripp et al. 2007. PubMed ID: 17551924; Rauen 2016. PubMed ID: 20301365), and Costello Syndrome (Gripp and Lin. 2012. PubMed ID: 20301680).


Noonan and Noonan-like syndromes are caused by pathogenic variants in PTPN11, SOS1, RAF1, KRAS, SHOC2, BRAF, NRAS, CBL, KAT6B, RIT1, SOS2, LZTR1, A2ML1, MAP3K8, RASA2, SPRY1, NF1 , and RRAS (Human Gene Mutation Database).

Pathogenic variants in the RRAS gene have been identified in patients presenting with features within the Noonan-spectrum disorders. Clinical features include a triangular face, downslanting palpebral fissures, congenital ptosis, low-set ears, thick lips, low posterior hairline, pulmonic stenosis, broad chest, crowded teeth, pyloric stenosis, glomerulonephritis, arthritis, and delayed acquisition of walking. Prenatal polyhydramnios has also been reported (Flex et al. 2014. PubMed ID: 24705357).

To date, two activating germline pathogenic variants in the RARS gene have been reported in two cases. These include a missense variant in a familial case and a de novo duplication of a single residue in a sporadic case. Evidence for pathogenicity include: (1) de novo occurrence of one of the identified variants; (2) localization of the identified variants in a known oncogene hotspot of the RRAS gene; and (3) positive modulatory role of the mutated RRAS proteins, reavealed by expression studies of the mutant proteins in a cell-model and in an experimental model (Flex et al. 2014. PubMed ID: 24705357).

The RRAS gene encodes a small monomeric GTPase, that has been involved in the control of cell adhesion and neurite outfrowth (Zhang et al. 1996. PubMed ID: 8620538; Keely et al. 1999. PubMed ID: 10352023).

Clinical Sensitivity - Sequencing with CNV PG-Select

Pathogenic variants in the RRAS gene appear to be a rare cause of Noonan syndrome. They have been identified in two individuals from a cohort of 504 patients presenting with phenotypes that overlap with features within Noonan spectrum disorders (Flex et al. 2014. PubMed ID: 24705357).

Testing Strategy

This test provides full coverage of all coding exons of the RRAS gene, plus ~10 bases of flanking noncoding DNA. We define full coverage as >20X NGS reads or Sanger sequencing.

Indications for Test

Candidates for this test are patients with clinical features suggestive of Noonan syndrome.


Official Gene Symbol OMIM ID
RRAS 165090
Inheritance Abbreviation
Autosomal Dominant AD
Autosomal Recessive AR
X-Linked XL
Mitochondrial MT


Name Inheritance OMIM ID


  • Allanson and Roberts. 2016. PubMed ID: 20301303
  • Allanson. 1987. PubMed ID: 3543368
  • Cao et al. 2017. PubMed ID: 28643916
  • Flex et al. 2014. PubMed ID: 24705357
  • Gripp and Lin. 2012 PubMed ID: 20301680
  • Gripp et al. 2007. PubMed ID: 17551924
  • Human Gene Mutation Database (Bio-base).
  • Keely et al. 1999. PubMed ID: 10352023
  • Rauen. 2016. PubMed ID: 20301365
  • Romano et al. 2010. PubMed ID: 20876176
  • Smpokou et al. 2012. PubMed ID: 23165751
  • Zhang et al. 1996. PubMed ID: 8620538


Ordering Options

We offer several options when ordering sequencing tests. For more information on these options, see our Ordering Instructions page. To view available options, click on the Order Options button within the test description.

myPrevent - Online Ordering

  • The test can be added to your online orders in the Summary and Pricing section.
  • Once the test has been added log in to myPrevent to fill out an online requisition form.
  • PGnome sequencing panels can be ordered via the myPrevent portal only at this time.

Requisition Form

  • A completed requisition form must accompany all specimens.
  • Billing information along with specimen and shipping instructions are within the requisition form.
  • All testing must be ordered by a qualified healthcare provider.

For Requisition Forms, visit our Forms page

Specimen Types

Specimen Requirements and Shipping Details

loading Loading... ×


An error has occurred while calculating the price. Please try again or contact us for assistance.

View Ordering Instructions

1) Select Test Method (Platform)

1) Select Test Type

2) Select Additional Test Options

STAT and Prenatal Test Options are not available with Patient Plus.

No Additional Test Options are available for this test.

Note: acceptable specimen types are whole blood and DNA from whole blood only.
Total Price: loading
Patient Prompt Pay Price: loading
A patient prompt pay discount is available if payment is made by the patient and received prior to the time of reporting.
Show Patient Prompt Pay Price
Copy Text to Clipboard