PreventionGenetics should be notified in advance of arrival of a prenatal specimen. For all prenatal testing in ongoing pregnancies, we require a signature from the health care provider on our PRENATAL HEALTH CARE PROVIDER'S STATEMENT FORM.
We accept fetal DNA, fetal tissue, cultured fetal cells, or direct CVS/amniotic fluid. However, acceptable specimen type is dependent on the fetal testing requested. Retention of a backup culture of the fetal cells is strongly recommended. Where possible, please ship cultured cells so that they will arrive at PreventionGenetics no later than Thursday in the work week. PreventionGenetics does not perform cell culture.
Maternal contamination of fetal sample will be tested using the PreventionGenetics DNA Genotyping Panel. Even in cases of autosomal dominant disorders in which the father has the causative mutation, blood or DNA from the mother is strongly encouraged to be sent for the contamination test. We do not charge extra for Maternal Cell Contamination studies, but the CPT Code, 81265, will be included on invoices and insurance claims as appropriate.
At this time, PreventionGenetics does not offer aCGH for prenatal specimens, however, if a copy number variation (CNV) was able to be confirmed by an alternate method (PCR) in a proband tested at PreventionGenetics, we may be able to offer targeted deletion or duplication testing prenatally. Please call and speak to one of our genetic counselors to see if this is a possibility. For any CNV where the mother is a carrier, we are unable to offer targeted testing for that CNV.
PreventionGenetics does not perform prenatal testing for sex. We will also not report fetal sex unless this is critical for interpretation of test results. PreventionGenetics does not perform pre-implantation DNA testing.
See our "Specimen Requirements" for acceptable prenatal specimens.
Familial Variant Testing (Test Code 990, $990) Order
Familial variants must be known in advance from testing of parents, affected siblings or other relatives. These variants must be confirmed at PreventionGenetics in the parents and/or proband. Parental specimens may be sent in advance of the prenatal specimen. There is no additional charge for parental testing or for maternal cell contamination testing, however, additional CPT codes for parental and MCC testing may be included at time of invoicing. Turnaround Time: 8-10 calendar days from receipt of specimen and signed PROVIDER'S STATEMENT.
NextGen Sequencing for Ongoing Pregnancy (see standard prices listed on our web site)
We will also perform Next-Gen tests for ongoing pregnancies. We expect that the ordering provider will take responsibility for the appropriateness of the requested testing. There is no additional charge for maternal cell contamination testing. Turnaround Time: The great majority of NGS tests are completed within 28 days from date of specimen and signed PROVIDER'S STATEMENT receipt. Our formal STAT option is not available.We will courtesy prioritize requests related to ongoing pregnancies.
Full Gene Sequencing for Ongoing Pregnancy (see standard prices and test codes listed on our web site)
We will also perform Sanger full gene sequencing tests for ongoing pregnancies. We expect that the ordering provider will take responsibility for the appropriateness of the requested testing. There is no additional charge for maternal cell contamination testing. Turnaround Time: The great majority of Sanger tests are completed within 18 days from date of specimen and signed PROVIDER'S STATEMENT receipt for a single gene. Our STAT option is available for a 25% additional charge. The great majority of STAT requests are completed within 8 calendar days. If we are unable to complete STAT requests within 10 days, the surcharge will be waived.
Testing in Cases of Fetal Demise or Pregnancy Termination (see standard prices listed on our web site)
In the case of fetal demise or pregnancy termination, no "PRENATAL HEALTH CARE PROVIDER'S STATEMENT" is required. Our standard specimen requirements and turnaround times apply.