Xeris Pharmaceuticals Uncovering Periodic Paralysis

Patients must:

• Be 18 years or older
• Live in the United States or a US territory
• Have a history of episodic muscle weakness/paralysis attacks or episodic pain after attacks (more than one occurrence)
• Have episodes provoked by at least one of the common triggers for hyperkalemic or hypokalemic primary periodic paralysis
• Hyperkalemic Primary Periodic Paralysis is is associated with episodes of weakness and/or paralysis with a documented serum potassium >4.5 mEq/L
• Triggers may include:
• • Exposure to cold
  • Rest after exercise
  • Stress or fatigue
  • Potassium-rich food
  • Hunger/fasting
• Hypokalemic Primary Periodic Paralysis is associated with focal or generalized paralytic episodes of skeletal muscle, which can last from hours to days and is associated with concomitant hypokalemia (>2.5 mEq/L)
• Triggers may include:
• • Rest after exercise
  • Carbohydrate-rich meals
  • Alcohol
  • Stress