Deafness, Autosomal Recessive 74 (DFNB74) via the MSRB3 Gene

Nonsyndromic hearing loss and deafness due to variants in the MSRB3 gene is suspected in individuals with the following: prelingual, bilateral, profound sensorineural hearing impairment; no related systemic findings identified by medical history and physical examination; and/or a family history of nonsyndromic hearing loss consistent with autosomal recessive inheritance. This test may also be considered for the reproductive partners of individuals who carry pathogenic variants in MSRB3.